Sabah completed their doctorate at UC Merced, investigating marine cone snail Californiconus californicus (the California Cone Snail) as part of larger venom microbiome research.
Voltage-gated calcium channel impairing toxin (Cav channel inhibitor) Channel Voltage-gated calcium channels (Cav) are the key signal transducers of electrical signaling, converting depolarization of the cell membrane to an influx of calcium ions that initiates contraction, secretion, neurotransmission and other intracellular regulatory events. L. Limpalaër, E. Monnier Xenophora Taxonomy Volume 19: 3-8 Pictoconus, new genus from South Africa and Profundiconinae, new subfamily (Gastropoda: Conidae).
Cone venom contains a very powerful neurotoxin, know as a conotoxin, which blocks nerve action. About 85% of the species cluster in the single Large Major Clade; the others are divided between the Small Major Clade (∼ 12%), the Conus californicus lineage (one species), and a newly defined clade (∼ 3%). We also define several subclades within the Large and Small major clades, but most of their relationships remain poorly supported.
(2019) The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity. This "Cited by" count includes citations to the following articles in Scholar. Merged citations. Most fatalities happen when the blocked nerve action results in respiratory failure. Bernáldez-Sarabia, J, Figueroa-Montiel A, Dueñas S, Cervantes-Luévano K, Beltrán JA, Ortiz E, Jiménez S, Possani LD, Paniagua-Solís JF, Gonzalez-Canudas J, Licea-Navarro A.
One of them includes two specimens identified as Lilliconus sagei (Korn & Raybaudi Massilia, 1993) (Fig. Ul-Hasan, Sabah – ProQuest LLC, 2019. To answer your third question, that work is still ongoing. The ones marked * may be different from the article in the profile. When presented with a fish, individuals of Californiconus californicus attempt to harpoon the fish, often succeeding even when the fish prey is larger than the cone snail.
Unlike some venomous animals, larger Cone Snails deliver more venom per sting than smaller individuals. Add co-authors Co-authors.
2 D, E). Direct link. The primary question of my dissertation is, "Does venom possess a microbiome specific to it as an ecosystem, and why?"
Yes, exactly. Their combined citations are counted only for the first article. “I spent a good portion of 2016 and all of 2017 looking for C. californicus across the California-Baja coast and spots where they are most abundant are Monterey, San Diego, and Puerto Nuevo.” Ul-Hasan’s thesis is on cone snails, C. californicus in particular, as a model system for venom-microbe interactions. In the course of the preparation of a forthcoming Iconography of living Conidae the necessity to introduce two new supraspecific group names appeared.
The Utility of Marine Neogastropod "Californiconus Californicus" as a Model System for Investigation of the Venom Microbiome.
The VGSC-targeted venom peptides in these other genera of the family Conidae are largely uncharacterized, except for work carried out on Californiconus californicus by Gilly and coworkers (Elliger et al., 2011, Gilly et al., 2011), but a biochemical characterization of VGSC-targeted toxins has not yet been reported.